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Methadone is contraindicated hinein patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in methadone hydrochloride tablets.
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Teratogenic Effects. Pregnancy Category C – There are no controlled studies of methadone use in pregnant women that can be used to establish safety. However, an expert review of published data on experiences with methadone use during pregnancy by the Teratogen Information Anlage (TERIS) concluded that maternal use of methadone during pregnancy as part of a supervised, therapeutic regimen is unlikely to Stellung a substantial teratogenic risk (quantity and quality of data assessed as “limited to ritterlich”). However, the data are insufficient to state that there is no risk (TERIS, bürde reviewed October, 2002). Pregnant women involved rein methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.
Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported hinein patients receiving doses commonly used for maintenance treatment of opioid addiction.
The total daily dose, potency and specific characteristics of the opioid the patient had been taking previously, if any;
Since methadone is lipophilic, it has been known to persist hinein the liver and other tissues. The slow release from the liver and other tissues may prolong the duration of methadone action despite low plasma concentrations.
Methadone is also used to manage drug addiction. If you have an addiction to another opioid, your doctor may give you methadone to prevent you from having severe withdrawal symptoms.
These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration.
Methadone can cause mild or serious side effects. The following Trick contains some of the key side effects that may occur while taking methadone. This list doesn’t include all possible side effects.
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Hinein contrast, methadone tested positive rein the hinein vivo mouse dominant lethal assay and the hinein vivo mammalian spermatogonial chromosome aberration test. Additionally, methadone tested positive rein the E. coli Dns repair Struktur and Neurospora crassa and maus lymphoma forward mutation assays.
The safety and effectiveness of this drug hasn’t been established in children. It shouldn’t Beryllium used rein children younger than 18 years.
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Primary attention should Beryllium given to the reestablishment of adequate respiratory exchange through Bonus of a patent airway and institution of assisted or controlled ventilation. If a non-tolerant person, takes a large dose of methadone, effective opioid antagonists are available to counteract the potentially lethal respiratory depression. The physician must remember, however, that methadone is a long-acting depressant (36 to 48 hours), whereas opioid antagonists act for much shorter Methadontabletten 10 mg online periods (one to three hours).